YHWH's Lament is a relic found in The Darkness II. It is a seashell through which one could hear the voice of God.
The Darkness feeds on human suffering, of which there was apparently plenty during the time of Noah. At that time, the Angelus was unwilling to intervene, so God did. He instructed Noah to build an Ark, then floods the entire Earth, supposedly destroying the Darkness. According to Johnny Powell, God, seeing that the Darkness survived, breathed His remorse into the first seashell Noah found after he left the Ark. If someone places the shell next to his ear, he could hear God's voice. However, only those who are extremely insane or near death can fathom God's words.
The relic is found in the back of Canal St. subway station.